Dermaseptin-PT9 [D8K,E23K] peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0008820
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Dermaseptin-PT9 (DPT9) (sequence: GLWSKIKDAAKTAGKAALGFVNEMV-NH2) is a novel dermaseptin peptide isolated and identified from Phyllomedusa tarsius by the combination of molecular cloning and LC-MS analysis. Chemically synthesised DPT9 was broadly effective against the tested microorganisms through the disruption of cell membranes and showed weak haemolytic activity towards horse erythrocytes. It also exhibited anti-proliferative effect against various human cancer cells. Dermaseptin-PT9 [D8K,E23K] (sequence: GLWSKIKKAAKTAGKAALGFVNKMV-NH2) is an analoge of DPT9, had a markedly increased antimicrobial effect against all tested microorganisms and disrupted microbial cell membranes. This analogue also showed no haemolysis at its effective antimicrobial concentrations. In addition, Dermaseptin-PT9 [D8K,E23K] displayed an enhanced anti-proliferative effect against cancer cells, while displayed weak activity against the normal human cell line, HMEC-1.
| Product Name: | Dermaseptin-PT9 [D8K,E23K] peptide |
| Molecular Formula: | C121H206N34O28S |
| Molecular Weight: | 2617.2 |
| Sequence: | H-GLWSKIKKAAKTAGKAALGFVNKMV-Amidation |
| Three letter code: | H-Gly-Leu-Trp-Ser-Lys-Ile-Lys-Lys-Ala-Ala-Lys-Thr-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Phe-Val-Asn-Lys-Met-Val-Amidation |
| Length (aa): | 37 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Dermaseptin-PT9 [D8K,E23K] peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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