Papiliocin peptide
For research use only. NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE.
Catalog Number: MPE0008956
Product Quantity: 5mg/20mg
Price: Varies
Availability: In Stock
Product Information
Injection of bacterial LPS induces the production of this peptide. Although papiliocin displayed a broad antimicrobial spectrum, it is not hemolytic and especially active against Gram-negative bacteria. This cecropin-like membrane-active peptide may form a pore (2.3-3.3 nm) in the fungal membranes (J Microbiol Biotechnol. 2010 Aug;20(8):1185-8). It could also induce yeast apoptosis (Hwang B et al 2011 Biochem Biophys Res Commun. 408: 89-93). The peptide also showed antiinfammatory activities. In DPC micelles, the peptide adopted a helix-hinge-helix conformation (H1:residues 3-21 and H2: 25-36). Residues W2 and F5 are proposed to be important for LPS binding (Kim JK et al. 2011 J Biol Chem 286:41296-311). Updated 10/24/11; 12/23/11 GW. Papiliocin has Antibacterial, Antifungal activity. The source of Papiliocin is the swallowtail butterfly, Papilio xuthus.
| Product Name: | Papiliocin peptide |
| Sequence: | RWKIFKKIEKVGRNVRDGIIKAGPAVAVVGQAATVVK |
| Three letter code: | Arg-Trp-Lys-Ile-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Arg-Asn-Val-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Ala-Thr-Val-Val-Lys |
| Length (aa): | 37 |
| Peptide Purity (HPLC): | >95%; 98% and 99% purity available upon request |
| Quantity/Unit: | 1 Vial |
| * Optional Service: | TFA Removal Service is available upon request. |
Technical Information
| Source: | Synthetic |
| Storage Guidelines: | Store at -20°C for up to 1 year. should be refrigerated after reconstitution. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides |
| Solubility: | Soluble in water |
| Appearance: | White to off-white powder |
| Shipping: | Peptides are shipped at ambient temperature by standard shipment process. |
| About TFA salt: | Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA. TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others. It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR. TFA Removal Service is recommended for: > Peptides that will be used in cellular assays > Peptides that will be used as APIs or in manufactured products > For hydrophilic peptides containing numerous basic residues |
Related Products / Services
Custom Peptide Synthesis: Papiliocin peptide peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression. Read more...
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